河北医学2017，Vol.23Issue(2)：204-208,5.DOI:10.3969/j.issn.1006-6233.2017.02.009
TE与TEC新辅助化疗方案对乳腺癌患者外周血CTCs及TSCs的影响
TE and TEC Neoadjuvant Chemotherapy on CTCs and TSCs in Peripheral Blood of Patients with Breast Cancer
摘要
Abstract
Objective: To analyze the effect of TE and TEC neoadjuvant chemotherapy on CTCs and TSCs in peripheral blood of patients with breast cancer. Methods: 155 cases of patients with breast cancer were selected from January 2015 to June 2016 in our hospital. The patients were divided into control group ( 77 cases) and observation group (78 cases) according to the random number table method. The patients in con-trol group were treated with TE regimen, the observation group received TEC regimen, the curative effect, ad-verse reaction, CTCs and TSCs level in the two groups were observed. Results: Compared with the control group, the effective rate of the observation group was 89.7%, the difference was not significant (χ2=0.932, P>0.05) , the neutrophils in the observation group were significantly more, the difference was significant (χ2=8.923,P<0.05) , but there was no significant difference in gastrointestinal tract reaction, cardiotoxicity, liver function abnormality, thrombocytopenia, alopecia and serum albumin (P>0.05). Compared with the control group, there was no significant difference in CTCs level between the observation group and the control group (χ2=1.293, 1.441, 0.992, P>0.05). There was no significant difference in TSCs between the two groups (χ2=1.903, 1.783, P>0.05) , but the level of TSCs in stageⅢwas significantly lower than that in stageⅢ(χ2= 7.543, P<0.05). Conclusion: The TE and TEC neoadjuvant chemotherapy for breast cancer patients with similar clinical efficacy, TEC program to reduce stage Ⅲ breast cancer patients with peripheral blood TSCs may be better than the TE program.关键词
新辅助化疗方案/乳腺癌/肿瘤干细胞/循环肿瘤细胞Key words
Neoadjuvant chemotherapy/Breast cancer/Cancer stem cells/Circulating tumor cells引用本文复制引用
汪忠淼..TE与TEC新辅助化疗方案对乳腺癌患者外周血CTCs及TSCs的影响[J].河北医学,2017,23(2):204-208,5.基金项目
辽宁省科技厅科学技术研究项目,(编号:A201225624CK) （编号:A201225624CK）
