河北医学2017，Vol.23Issue(2)：263-266,4.DOI:10.3969/j.issn.1006-6233.2017.02.026
血清高尔基体膜蛋白73在原发性肝细胞癌早期诊断中的应用
The Application of Serum Golgi Membrane Protein 73 in Early Diagnosis of Primary Hepatocellular Carcinoma
摘要
Abstract
Objective:To investigate the clinical value of serum Golgi membrane protein 73 ( GP73) in the diagnosis of primary hepatocellular carcinoma (HCC).Methods:300 people including healthy people, out-patient and inpatient in our hospital from July 2014 to July 2015 were divided respectively into five groups as HCC group, posthepatitic b cirrhosis group, other malignant tumor group, chronic hepatitis B group and healthy control group. The level of Serum GP73 and alpha fetoprotein (AFP) were determined and the ROC curve of its diagnostic HCC was drawn. Result:There was no significant difference in the level of serum GP73 of the patients with different age, tumor size, gender and concentration of serum AFP in the HCC group ( P>0.05) . The level of serum AFP and GP73 of the patients in the HCC group were significantly higher than that in the other groups( P<0.05) , while the level of serum AFP and GP73 of the patients in the chronic hepatitis B, posthepatitic b cirrhosis group and other malignant tumor group were significantly higher than that of the healthy control group( P<0.05) . The specificity and sensitivity of GP73 in the diagnosis of HCC were signifi-cantly higher than those of AFP, P<0.05. Conclusion: The sensitivity and specificity of serum GP73 in the diagnosis of HCC are better than those of AFP. GP73 can be a serum marker in the early diagnosis of HCC.关键词
原发性肝细胞癌/GP73/慢性乙型肝炎/乙肝后肝硬化/恶性肿瘤/早期诊断Key words
Primary hepatocellular carcinoma/GP73/Chronic hepatitis B/Posthepatitic b cir-rhosis/Malignant tumor/early diagnosis引用本文复制引用
陈飞,曾传琴,欧彬..血清高尔基体膜蛋白73在原发性肝细胞癌早期诊断中的应用[J].河北医学,2017,23(2):263-266,4.基金项目
四川省科技厅科研课题,(编号:2013JY02541) （编号:2013JY02541）
