郑州大学学报（医学版）2017，Vol.52Issue(2)：209-212,4.DOI:10.13705/j.issn.1671-6825.2017.02.026
HDL-C与非瓣膜性房颤左心房血栓形成的关系
Relationship between high-density lipoprotein cholesterol and left atrial thrombus in nonvalvular atrial fibrillation patients
景莉娟 1陶海龙 1李凌 1白中乐 1孟哲 1王梦雨1
作者信息
- 1. 郑州大学第一附属医院心血管内科 郑州 450052
- 折叠
摘要
Abstract
Aim: To investigate the relationship between high-density lipoprotein cholesterol ( HDL-C) and left atrial thrombus in nonvalvular atrial fibrillation (AF) patients.Methods: A total of 473 patients with nonvalvular AF who were admitted in our department for radiofrequency catheter ablation were enrolled .The patients were allocated into thrombus group ( n=60 ) and non-thrombus group ( n=413 ) according to transesophageal echocardiography .All baseline clinical characteristics, CHA2DS2-VASc score, laboratory examination results(HDL-C included) and echocardiographic parameters were analyzed.Results:Higher CHA2DS2-VASc score(OR=1.649,95%CI:1.238-2.197,P=0.001), persistent AF (OR=3.424,95%CI:1.718-6.821,P<0.001) were the independent risk factors for left atrial thrombus , while HDL-C (OR=0.299,95%CI:0.097-0.924,P=0.036) was the independent protective factor .ROC curves showed that the AUC of CHA2DS2-VASc score to predict left atrial thrombus in nonvalvular atrial fibrillation patients was 0.717 ( 95%CI:0.671-0.759,P<0.001), and the AUC of HDL-C combined with CHA2DS2-VASc score and persistent AF was 0.791 (95%CI:0.749-0.829,P<0.001).Conclusion:Low HDL-C level is a high risk factor for left atrial thrombus .Combi-ning HDL-C level with CHA2DS2-VASc score and persistent AF to predict left atrial thrombus in nonvalvular atrial fibrilla-tion patients is superior to CHA2DS2-VASc score.关键词
心房颤动/高密度脂蛋白胆固醇/左心房/血栓Key words
atrial fibrillation/high-density lipoprotein cholesterol/left atrial/thrombus分类
医药卫生引用本文复制引用
景莉娟,陶海龙,李凌,白中乐,孟哲,王梦雨..HDL-C与非瓣膜性房颤左心房血栓形成的关系[J].郑州大学学报（医学版）,2017,52(2):209-212,4.
