中国实用神经疾病杂志2017，Vol.20Issue(5)：11-16,6.
急性缺血性脑卒中患者脑灌注改变与可能干预靶点
Changes of cerebral reperfusion and potential targets for intervention in acute ischemic stroke
刘媛 1彭建伟 2于联芳2
作者信息
- 1. 新乡医学院硕士研究生 新乡 453000
- 2. 解放军第 153 中心医院神经内科 郑州 450041
- 折叠
摘要
Abstract
Objective To observe the changes of cerebral perfusion parameters in ischemic lesion and its surrounding area, and to explore the possible targets for clinical intervention in acute ischemic stroke.Methods Consecutive in-patients with acute ischemic stroke with less than 72 hours of symptom onset from March 2015 to March 2016 were enrolled and all patients received magnetic resonance perfusion weighted imaging within 24 to 48 hours after being admitted to hospital.Cerebral perfusion parame-ters includedcerebral blood volume (CBV),cerebral blood flow (CBF),mean transit time (MTT)and time to peak (TTP).All pa-tients were divided into normal perfusion group and abnormal perfusion group according to the result of visual assessment.Image fusion technique and concentric circle calibration method were used to localize the region of interest (ROI)and itsmirror of interest (ROM)and then the values of them were automatically calculated.ROI/ROM (rCBV,rCBF,rMTT,rTTP)regarded as relative value was compared.Results Of the included 158 cases,113 cases presented abnormal perfusion and 45 casespresented normal perfusion diagnosed by visual assessment,with an abnormal perfusion rate of 72%.Either ischemic lesion or its surrounding area showed increase of rCBV,reduction of rCBF and extension of both rMTT and rTTP in the abnormal perfusion group,all of which displayed statistical differences compared with the normal perfusion group (all P<0.01).It suggested that hypo-perfusion existed in ischemic lesion or its surrounding area in the abnormal perfusion group because of the reduction of CBV and blood stasis oc-curreddue to the extension of both MTT and TTP.Conversely,the normal perfusion grouppresented hyper-perfusion and no obvi-ous stasis.As a result,improvement of CBV inischemic lesion or its surrounding area might become a possible target for clinical in-tervention.Conclusion Improving CBV in ischemic lesion or its surrounding area may be a possible target for clinical intervention and a promising criterion of obj ective j udgment for clinical treatment.关键词
急性缺血性脑卒中/磁共振灌注成像/脑血容量Key words
Acute ischenic Stroke/Magnetic resonance perfusion weighted imaging/Cerebral blood volume分类
医药卫生引用本文复制引用
刘媛,彭建伟,于联芳..急性缺血性脑卒中患者脑灌注改变与可能干预靶点[J].中国实用神经疾病杂志,2017,20(5):11-16,6.
