中国实用神经疾病杂志2017，Vol.20Issue(6)：5-9,5.
A型肉毒素局部注射结合强化运动治疗对脑卒中后下肢痉挛患者步行能力的影响
The effects of local injection with botulinum toxin type A uniting with intensive physical therapy on walking abil-ity in patients with post-stroke spasticity of lower limbs
摘要
Abstract
Objective To preliminaprily observe the effects of local injection with botulinum toxin type A uniting with in-tensive physical therapy on walking ability in patients with post-stroke spasticity of lower limbs.Methods Forty patients with post-stroke spasticity of lower limbs were randomly divided into treatment group and control group,20 patients in each group.The control group received local injection with botulinum toxin type A in the spastic muscles of lower limbs and other conventional re-habilitation therapy.The treatment group received intensive physical therapy on the basis of control group.Before and four,eight weeks after treatment,the two groups were comparatively scored in MAS(Modified Ashworth Scale),IEMG(muscle surface elec-tromyography integral value),PROM(passive range of motion),10 m MWS(10m fastest walking speed),FMA(Fugl-Meyer motor function)and PCI(physiological consumption index).Results Four and eight weeks after treatment,MAS,IEMG,PROM,10 m MWS,FMA and PCI scores were significantly improved in the two groups(P<0.05).Four weeks after treatment,PROM(4.39± 1.25)°,10 m MWS(18.12±3.47)m/s,FMA(25.16±2.55),PCI(0.51±0.21)and other indicators in the treatment group were significantly better than those in the control group,and all the differences were statistically significant(P<0.05),while the MAS (1.54±0.48)and IEMG(37.95±4.48)showed no significant differences(P>0.05).After eight-week treatment,PROM(4.42± 1.01)°,10 m MWS(14.11±2.83)m/s and other indicators in the treatment group were significantly superior to those in the con-trol group(P<0.05),but MAS(1.63±0.57),IEMG(46.94±8.17),FMA(26.44±2.12),PCI(0.47±0.15)and other indicators showed no significant differences(P>0.05).Conclusion Local injection with botulinum toxin type A uniting with intensive physi-cal therapy which can effectively improve walking ability in patients with post-stroke spasticity of lower limbs,should be consid-ered as an available rehabilitation therapy.关键词
下肢痉挛/A型肉毒毒素/强化运动治疗/步行能力Key words
Spasticity of lower limbs/Botulinum toxin type A/Intensive physical therapy/Walking ability分类
医药卫生引用本文复制引用
李亚斌,冯海霞,白佳佳,苏明莉,韩丽媛,包爱强,梁学镖,乔小红..A型肉毒素局部注射结合强化运动治疗对脑卒中后下肢痉挛患者步行能力的影响[J].中国实用神经疾病杂志,2017,20(6):5-9,5.基金项目
甘肃省自然科学基金项目(145RJZA107) （145RJZA107）
