湖南中医药大学学报2017，Vol.37Issue(3)：245-248,4.DOI:10.3969/j.issn.1674-070X.2017.03.004
高血压心力衰竭大鼠动物模型的研制
Building of Hypertensive Heart Failure Rat Models
摘要
Abstract
Objective To build the rat model of hypertension heart failure. Methods Eighteen Dahl salt sensitive rats were divided into normal group and model group feed by 0.3% NaCl low-salt and 8% NaCl high-salt for 20 weeks, respec-tively. After 20 weeks, the daily behavior and physical signs of the rats were observed. The blood pressure, serum N-termi-nal-pro-brain-natriuretic-peptide (NT-proBNP) content of the rats were observed. The left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were measured by color doppler ultrasound instrument. The HE dyed myocardial cells and kidney tissue were observed by electron microscope of the rats. Results Blood pressure of normal group rats maintained at about 140 mmHg, and blood pressure of the model group rats kept rising up to 250 mmHg after eat-ing high-salt feed. Compared with normal group, there are significant differences in the NT-proBNP, LVEF and LVFS (P<0.01). Conclusion The rats model can well simulate the disease process that normal secondary hypertension rats develop hypertensive heart failure rats. The rat model can be used for the research of hypertensive heart failure disease.关键词
高血压/心力衰竭,Dahl盐敏感性大鼠/大鼠动物模型Key words
hypertension/heart failure/Dahl salt sensitive rats/rat models分类
医药卫生引用本文复制引用
李欣春,梁昊,胡志希,胡思远,文阳,钟森杰,李琳..高血压心力衰竭大鼠动物模型的研制[J].湖南中医药大学学报,2017,37(3):245-248,4.基金项目
国家自然科学基金项目(81373550). （81373550）
