基础医学与临床2017，Vol.37Issue(3)：422-426,5.
阿片类药物呼吸抑制作用的机制研究进展
Research progress in mechanisms of opioids-induced respiratory depression
刘孝文 1刘真 1赵晶1
作者信息
- 1. 中国医学科学院北京协和医学院北京协和医院麻醉科, 北京100730
- 折叠
摘要
Abstract
Respiratory depression is a common adverse effect of opioids .Currently, the mechanisms and manage-ment of opioid-induced respiratory depression ( OIRD) are one of the research foci .OIRD arises from stimulation ofμ-opioid receptors in the pre-Botzinger complex and the Kolliker-Fuse neurons .Adenylyl cyclase , calcium chan-nels, and G-protein-gated inwardly rectifying potassium (GIRK) channels may be the key cellular signaling mecha-nisms of OIRD .关键词
阿片类药物/阿片受体/呼吸抑制Key words
opioids/opioid receptors/respiratory depression分类
医药卫生引用本文复制引用
刘孝文,刘真,赵晶..阿片类药物呼吸抑制作用的机制研究进展[J].基础医学与临床,2017,37(3):422-426,5.
