吉林中医药2017，Vol.37Issue(3)：276-280,5.DOI:10.13463/j.cnki.jlzyy.2017.03.017
鹿茸多肽提取物抗去卵巢大鼠骨质疏松作用的研究
Study on extract of pilose antler polypeptides anti osteoporosis effect to ovariectomized rats
摘要
Abstract
Objective To study the effects of pilose antler polypeptide extracts on ovariectomized rats induced osteoporosis. Methods 60 Wistar female rats were adaptive fed one week, free drinking water. All rats were divided to sham operation group, model group, positive group and antler polypeptide extract high dose group, middle dose group and low dose group according to the weight. Osteoporosis model was established by bilateral ovariectomy, after two weeks, the rats were given intragastric administration (Ig), to observe the antler polypeptide extract on bone density in rats after 13 weeks of administration (BMD), serum alkaline phosphatase (ALP), estradiol (E2) and phosphorus (P), calcium (Ga), creatinine (Gr) and other indicators, and effects of kidney, uterus, vagina index. Results Compared with the model group, the extract of pilose antler polypeptides can significantly improve extract serum, bone mineral density of ovariectomized rats in E2, P, Ga, Gr and ALP index. Conclusion The extract of pilose antler polypeptides can be effective in the treatment of osteoporosis in ovariectomized rats.关键词
鹿茸多肽提取物/去卵巢大鼠/骨质疏松/骨密度Key words
extract of pilose antler polypeptides/ovariectomized rats/osteoporosis/bone mineral density分类
医药卫生引用本文复制引用
李斌,曹金霞,王保森,闫文昊,仇志凯,林贺,律广富,林喆..鹿茸多肽提取物抗去卵巢大鼠骨质疏松作用的研究[J].吉林中医药,2017,37(3):276-280,5.基金项目
吉林省中医药科技项目(2014-ZD9). （2014-ZD9）
