计算机工程与应用2017，Vol.53Issue(5)：212-215,4.DOI:10.3778/j.issn.1002-8331.1606-0270
凝胶图像重叠蛋白质点分割算法研究
Research on segmentation algorithm of overlapping protein spots in two-dimensional gel electrophoresis image s
摘要
Abstract
A segmentation method of overlapping protein spots is proposed for detection of overlapping protein spots in two-dimensional gel electrophoresis images, which is based on the combination of corner detection and polygonal approxi-mation. First, Harris corner detector is used to distinguish the corner points from the overlapping protein spots. Second, the corner points are used to make polygonal approximation of protein spots and the concave corner points are obtained by judging the convexity and concavity of polygonal vertices. Finally, overlapping protein spots are separated by constructing the segmentation lines while selecting the concave points from the concave corner points under the concave points selecting and matching rule. Experimental results show that the method can be used to separate the overlapping protein spots accurately, especially the severe overlapping protein spots.关键词
重叠蛋白质点/角点检测/多边形近似/凹点/分割Key words
overlapping protein spots/corner detection/polygon approximation/concave point/segmentation分类
信息技术与安全科学引用本文复制引用
赵福娟,李玲,辛化梅..凝胶图像重叠蛋白质点分割算法研究[J].计算机工程与应用,2017,53(5):212-215,4.基金项目
国家自然科学基金(No.61401259) （No.61401259）
中国博士后科学基金(No.2015M582128). （No.2015M582128）
