实用临床医药杂志2017，Vol.21Issue(1)：34-36,3.DOI:10.7619/jcmp.201701010
哮喘患者GLCCI1基因检测指导吸入糖皮质激素的安全性用药效果
Effect of inhaled corticosteroids guided by GLCCI1 gene detection on treatment of patients with asthma
摘要
Abstract
Objective To explore the clinical value of GLCCI1 gene detection in guiding administration of inhaled corticosteroids in patients with asthma.Methods Eighty asthma patients were divided into wild type allele group (n =64) and mutant type allele group (n =16) according to GLCCI1 gene detection.Both groups were treated with budesonide aerosol,and the clinical effect was compared between two groups.Results In wild type allele group,the total effective rate was 92.2％ and the incidence rate of adverse reaction was 7.8％,which were significantly better than 75.0％ and 25.0％ in mutant type allele group (P ＜ 0.05).There were significant differences in FEV1,FEV/FVC ratio,FVC and PEF between two groups (P ＜ 0.05).Conclusion The GLCCI1 gene detectiou can significantly improve the effect of inhaled corticosteroids and reduce the incidence rate of adverse reactions.关键词
哮喘/糖皮质激素诱导的转录基因1/糖皮质激素/布地奈德气雾剂Key words
asthma/gene transcription induced by glucocorticoid 1/inhaled corticosteroids/budesonide aerosol分类
医药卫生引用本文复制引用
王星翘,尹琴,王天祺,黄文,李松明..哮喘患者GLCCI1基因检测指导吸入糖皮质激素的安全性用药效果[J].实用临床医药杂志,2017,21(1):34-36,3.基金项目
湖北省卫计委科研基金一般性项目(WJ2015MB126) （WJ2015MB126）
