实用临床医药杂志2017，Vol.21Issue(1)：65-67,3.DOI:10.7619/jcmp.201701019
早期微孔手术治疗中小量基底节脑出血后脑水肿的疗效及对血清炎性因子的影响
Clinical efficacy of early micro-porous surgery in treatment of patients with encephaledema after small-and moderate-volume basal ganglia hemorrhage and its influence on serum inflammatory factors
李晖 1戴孝森 1侯德文 1王进昆2
作者信息
- 1. 四川省遂宁市中医院脑病中心神经外科,四川遂宁,629000
- 2. 昆明医科大学第一附属医院神经外科,云南昆明,650032
- 折叠
摘要
Abstract
Objective To explore the clinical efficacy of early micro-porous surgery in the treatment of patients with encephaledema after small-and moderate-volume basal ganglia hemorrhage and its influence on serum inflammatory factors.Methods A total of 104 patients with small-and moderate-volume basal ganglia hemorrhage were randomly divided into control group and observation group,52 cases in each group.Control group was treated with conventional treatment,while observation group was treated with early micro-porous surgery.The volume of encephaledema and clearance time of hematoma 3 d and 14 d after treatment were observed in both groups.The levels of serum interleukin-6 (IL-6),IL-13 and tumor necrosis factors-α (TNF-o) were detected before treatment and 3 d after treatment in both groups.National Institutes of Health Stroke Scale (NIHSS) and Activities of Daily Life Function Assessment Scale Barthel index (BI) were used before and 3 weeks after treatment to evaluate patients' neurological function.Results The 3 d and 14 d after treatment,observation group was significantly smaller in volume of encephaledema (P ＜ 0.05) and shorter in clearance time of hematoma (P ＜0.01) when compared with control group.Three days after treatment,levels of serum IL-6,IL-1 β and TNF-α decreased significantly in both groups,which decreased more significantly in observation group than in control group (P ＜0.05 or P ＜0.01).Three weeks after treatment,NIHSS score decreased significantly while BI increased significantly in both groups,which improved more significantly in observation group than in control group (P ＜ 0.05).Conclusion Early micro-porous surgery can significantly relieve the severity of encephaledema after intracerebral hemorrhage,and has greater advantages in recovering patients' neurological function.关键词
微孔手术/中小量基底节脑出血后脑水肿/临床疗效/血清炎性因子/神经功能Key words
micro-porous surgery/encephaledema after small-and moderate-volume basal ganglia hemorrhage/clinical efficacy/serum inflammatory factors/neurological function分类
医药卫生引用本文复制引用
李晖,戴孝森,侯德文,王进昆..早期微孔手术治疗中小量基底节脑出血后脑水肿的疗效及对血清炎性因子的影响[J].实用临床医药杂志,2017,21(1):65-67,3.
