实用临床医药杂志2017，Vol.21Issue(3)：52-54,3.DOI:10.7619/jcmp.201703016
生长分化因子-15在垂体腺瘤中的表达及意义
Expression and significance of growth differentiation factor-15 in pituitary adenomas
摘要
Abstract
Objective To explore expression and significance of growth differentiation factor (GDF)-15 in pituitary adenomas.Methods A total of 100 tissue samples of patients with pituitary adenomas were selected and divided into invasive pituitary adenomas group (n =63) and non-pituitary adenomas group (n =37) according to aggressive condition,and 50 healthy people were selected as control group.The expression of GDF-15 was compared among the three groups,and the correlation between GDF-15 and the invasiveness of pituitary adenomas was analyzed.Results The level of GDF-15 in patients with prolactin secreting pituitary adenomas and growth hormone adenomas was significantly higher than that of patients with non-functional pituitary adenomas (P ＜ 0.05).The level of GDF-15 in the invasive pituitary adenomas group was significantly higher than the non-invasive group and the control group (P ＜ 0.05).The correlation analysis showed that there was a positive correlation between GDF-15 and invasive pituitary adenomas (r =0.328,P =0.001).Conclusion In patients with pituitary adenomas,the expression of GDF-15 is higher,and there is a correlation between the GDF-15 level and the invasiveness of pituitary adenomas.关键词
生长分化因子-15/垂体腺瘤/侵袭性Key words
growth differentiation factor-15/pituitary adenoma/invasiveness分类
医药卫生引用本文复制引用
刘明,许峥嵘,刘熙鹏,张志英,张秀峰,曹兵..生长分化因子-15在垂体腺瘤中的表达及意义[J].实用临床医药杂志,2017,21(3):52-54,3.基金项目
河北省张家口市科技攻关项目(1521082D) （1521082D）
