实用临床医药杂志2017，Vol.21Issue(3)：96-98,3.DOI:10.7619/jcmp.201703029
妊娠期高血压患者血清脂联素与胎盘基质金属蛋白酶-9的相关性研究
Study on the correlation between serum adiponectin and placental matrix metalloproteinase 9 in patients with gestational hypertension
张艳 1凃静 1黄晖1
作者信息
- 1. 湖北省恩施市中心医院妇产科,湖北恩施,445000
- 折叠
摘要
Abstract
Objective To explore the relationship between the level of serum adiponectin and placental matrix metalloproteinase 9 (MMP-9) in patients with gestational hypertension.Methods According to the severity of disease,145 patients with gestational hypertension were divided into mild gestational hypertension group (n =72) and severe gestational hypertension group (n =73),and 60 healthy pregnant women at the same time were selected as control group.The levels of serum adiponectin and MMP-9 expression were compared among three groups.Results Compared with control group,the levels of serum adiponectin in gestational hypertension groups decreased significantly (P ＜ 0.05).There was significant difference between gestational hypertension groups and control group in the positive rate of MMP-9 (P ＜ 0.05 or P ＜ 0.01).The positive rate of MMP-9 in severe gestational hypertension group was significantly lower than that in mild one and control group (P ＜0.01).The level of serum adiponectin was positively correlated with placental MMP-9 in the patients with gestational hypertension (r =0.71,P ＜ 0.05).Conclusion The decrease of serum adiponectin and the decreased expression of MMP-9 in placenta may promote the occurrence and development of gestational hypertension.关键词
妊娠期/高血压/脂联素/胎盘基质金属蛋白酶-9Key words
pregnancy/hypertension/adiponectin/placental matrix metalloproteinase 9分类
医药卫生引用本文复制引用
张艳,凃静,黄晖..妊娠期高血压患者血清脂联素与胎盘基质金属蛋白酶-9的相关性研究[J].实用临床医药杂志,2017,21(3):96-98,3.
