扬州大学学报（农业与生命科学版）2016，Vol.37Issue(4)：15-20,6.DOI:10.16872/j.cnki.1671-4652.2016.04.004
树突细胞及Th17/Treg在ICP患者的表达和临床意义
Expression and significance of dendritic cells and Th17/Treg in patients with Intrahepatic Cholestasis of Pregnancy
摘要
Abstract
30 cases of mild ICP,25 cases of severe ICP and 30 cases of normal pregnant women were selected.IHC and ELISA were used to evaluate the levels of dendritic cells,IL-17 and IL-35 in serum and placental tissues of patients with intrahepatic cholestasis of pregnancy.The expression of CD83+DCs,CD1a+DCs,IL-17 and IL-35 were detected.Results showed that there were more CD83+ DCs,IL-17 expressed in placenta from women with ICP than those in normal preg-nancies,while the number of decidual CD1a+ DCs,IL-35 was significantly lower in ICP than in normal pregnant women.The comparison between three groups had statistical difference (P＜0.05).CD83+ DCs and CD1a+ DCs had no significant difference in serum.IL-17 serum level was higher in ICP,while IL-35 serum level was lower in ICP.DCs was involved in damaging the maternal-fetal immune tolerance by changing the phenotype and mature state,which may affect the differentiation of Th17/Treg to cause ICP.关键词
妊娠期肝内胆汁淤积症/CD83+DCs/CD1a+DCs/IL-17/IL-35/免疫耐受Key words
intrahepatic cholestasis of pregnancy/CD83+DCs/CD1a+DCs/IL-17/IL-35/immune tolerance分类
医药卫生引用本文复制引用
孔艳,孔祥,张方圆..树突细胞及Th17/Treg在ICP患者的表达和临床意义[J].扬州大学学报（农业与生命科学版）,2016,37(4):15-20,6.基金项目
江苏省自然科学基金资助项目(BK20131230) （BK20131230）
