扬州大学学报（农业与生命科学版）2016，Vol.37Issue(4)：21-26,6.DOI:10.16872/j.cnki.1671-4652.2016.04.005
FAK在宫颈癌中的表达及临床意义
The expression and clinical significance of the FAK in cervical cancer
摘要
Abstract
The expression of focal adhesion kinase (FAK) in normal cervical tissues (n=35) and cervical cancer tissues (n=47) by immunohistochemical SP and qRT-PCR was investigated to explore its clinical significance.Results:① The expression of the FAK was significantly higher in cervical cancer than that in normal cervical tissues (P＜0.05).② FAK expression was higher in FIGO stage Ⅲ-Ⅳ than in stage Ⅰ-Ⅱ of cervical cancer tissues (P＜0.05).③ The expression of the FAK lower in cervical cancer tissues infiltration depth ＜1/2 organization than in infiltration depth＞1/2 organization (P＜0.05).④ The FAK expression was investigated to obviously increased in cervical cancer tissue with lymph node metastasis of cervical cancer compared to cancer tissue without lymph node (P＜0.05).The study indicated that the expression of FAK increased gradually along with the progression of the cervical cancer,which may be involved in the occurrence,invasion and metastasis process of cervical cancer,may be one of the high-risk biomarkers used as a judgment index from early cervical cancer to advanced cancer,and may provide a new predictive molecular target for diagnosis and prognosis of cervical cancer.关键词
宫颈癌/黏着斑激酶(FAK)/分子标靶Key words
cervical cancer/focal adhesion kinase (FAK)/molecular target分类
医药卫生引用本文复制引用
郝臻凤,王娟,周留林,刘静,孔桂美,杨纪实,钱静..FAK在宫颈癌中的表达及临床意义[J].扬州大学学报（农业与生命科学版）,2016,37(4):21-26,6.基金项目
国家自然科学基金资助项目(81272537、30801497) （81272537、30801497）
江苏省中医药局项目(LZ13206) （LZ13206）
