军事医学2017，Vol.41Issue(1)：58-61,4.DOI:10.7644/j.issn.1674-9960.2017.01.013
多西他赛磷脂／胆盐复合胶束的制备及性质研究
Preparation and characterization of docetaxel incorporated in phosphatidylcholine-sodium desoxycholate mixed micelles
胡巧巧 1付桂英 2王军玲 1孙旭婧2
作者信息
- 1. 安徽医科大学解放军307临床学院，合肥 230032
- 2. 军事医学科学院附属医院药学部，北京 100071
- 折叠
摘要
Abstract
Objective To prepare and characterize docetaxel incorporated phosphatidylcholine -sodium desoxycholate mixed micelles (DOX EPC/SDC MMs).Methods Docetaxel mixed micelles (DOX MMs) were prepared using the co-precipitation method .An optimized formulation was obtained by single factor method , which was used to study the effect of several factors on water solubility of DOX in MMs, including EPC/total(EPC+SDC)concentration, total(EPC+SDC) concentration, the pH and ionic strength of the hydrated solution .Then, the obtained DOX MMs were characterized by investigating particle size distribution and morphology , and by conducting dilute experiments to examin micelle stability . Results The EPC/total ( EPC+SDC) concentration ratio was 0.4.The total supplementary material concentration was 2.5%.Pure water was used to disperse the film .The drug loaded MMs had an average size of 18.56 nm and average zeta potential of -24.3 mV.A roundlike shape was observed under a transmission electron microscope ( TEM).Conclusion DOX EPC/SDC MMs, prepared by a simple and convenient method , can enhance water solubility , is physically compatible with injection solutions and is expected to become a new drug delivery system .关键词
多西他赛/磷脂/胆盐/复合胶束/溶解度Key words
docetaxel/phosphatidylcholine/bile salt/mixed micelles/solubility分类
医药卫生引用本文复制引用
胡巧巧,付桂英,王军玲,孙旭婧..多西他赛磷脂／胆盐复合胶束的制备及性质研究[J].军事医学,2017,41(1):58-61,4.
