解放军医学院学报2017，Vol.38Issue(1)：59-63,5.DOI:10.3969/j.issn.2095-5227.2017.01.016
RhoGTP酶在哺乳动物细胞失重/微重力适应中的作用研究进展
Progress on the role of RhoGTPase in mammalian cell adaptation to microgravity-related conditions
摘要
Abstract
A growing number of studies are revealing that mammalian cells reorganize their cytoskeleton when exposed to microgravity. Most of the structural changes observed on flown cells can be explained by modulation of RhoGTPases, which are mechanosensitive switches responsible for cytoskeletal dynamics control. This review outlines the general principles defining cell sensitivity to gravitational stresses. In order to enhance our understanding of cell adaptation to microgravity-related conditions, we discuss what is known about changes in cell shape, nucleus, andfocal adhesions and try to reveal their relationship with specific RhoGTPase activities.关键词
失重/微重力/RhoGTP酶Key words
weightlessness/microgravity/RhoGTPase分类
医药卫生引用本文复制引用
汤臻,顼红雨,王永春,谢超,高原,孙静,许波,赵疆东,李程飞..RhoGTP酶在哺乳动物细胞失重/微重力适应中的作用研究进展[J].解放军医学院学报,2017,38(1):59-63,5.基金项目
国家自然科学基金项目(81301681 （）
81372130 （）
8131682) （）
陕西省自然科学基金(2015SF108 （）
2016JM8030 （）
2016SF049) Supported by the National Natural Science Foundation of China (81301681 （）
81372130 （）
81301682) （）
Shaanxi Provincial Natural Science Foundation (2015 SF108 （）
2016JM8030 （）
2016SF049) （）
