解放军医学院学报2017，Vol.38Issue(1)：71-74,4.DOI:10.3969/j.issn.2095-5227.2017.01.019
肿瘤来源外泌体在机体免疫系统与肿瘤微环境中的作用及其临床应用前景
Function of tumor derived exosomes in human immune system and tumor microenviroment and its clinical application
摘要
Abstract
Exsomes are a kind of endocytosis-derived small vesicles with a size of 50- 100 nm,containing microRNA, mRNA, DNA fragment, protein and so on. They were secreted by immune cells, mesenchymal cells, tumor cells and many other kinds of cells through exocytic pathway, mainly transferred from donor cells to recipient cells. Tumor-derived exosomes have close relationship with tumor progression. On one hand, tumor-derived exosomes contributed to the construction of tumor microenvironment, on the other hand, tumor-derived exosomes have dual function of immunoenhancement and immunosuppression in human immune system. Exosomes have a potential to be biomarker in diagnosis and treatment of tumor. In this article, we will discuss the biogenesis and secretion of exosomes, and mainly emphasizes the function of tumor-derived exosomes in tumor microenvironment and immune system, and its prospect of clinical application.关键词
外泌体/肿瘤微环境/免疫/诊断/治疗Key words
exosomes/tumor microenvinroment/immune/diagnosis/therapy分类
医药卫生引用本文复制引用
王倩,肖文华..肿瘤来源外泌体在机体免疫系统与肿瘤微环境中的作用及其临床应用前景[J].解放军医学院学报,2017,38(1):71-74,4.基金项目
国家自然科学基金项目(81372220) Supported by the National Natural Science Foundation of China(81372220) （81372220）
