解放军医学院学报2017，Vol.38Issue(2)：97-100,131,5.DOI:10.3969/j.issn.2095-5227.2017.02.001
血清胱抑素C对不伴肾功能不全老年房颤患者心脑血管终点事件的影响
Effects of serum cystatin C on risks of cardiovascular events in elderly atrial fibrillation patients without renal insufficiency
摘要
Abstract
Objective To investigate the effects of serum Cystatin C on the risks of cardiovascular events in elderly atrial fibrillation patients without renal insufficiency [eGFR > 60 ml/(min · 1.73 m2)]. Methods Totally 356 elderly non-vavularatrial fibrillation patients without renal insufficiency were selected from July 2008 to June 2010 in this retrospective study. The baseline characteristics and clinical adverse events were recorded. The patients were divided into two groups according to the median value of baseline serum Cystatin C concentration (1.15 mg/L). Multivariate Cox regression analysis was adopted to calculate the adjusted hazard ratio (HR) of elevated serum Cystatin C concentration for clinical adverse events. Results During a mean follow-up period of 37.8 months, 97 patients died and 27 patients died of cardiovascular diseases. A total of 74 patients had thromboembolic events and 56 patients had cardiovascular events. After adjusting for other traditional risk factors, serum Cystatin C≥1.15 mg/Lwas an independent predictor of all-cause death (HR:2.250, 95% CI: 1.460-3.468, P < 0.001), cardiovascular death (HR:3.695, 95% CI: 1.536-8.889, P=0.004), thromboembolic event (HR:1.725, 95% CI: 1.055-2.819, P=0.030) and cardiovascular event (HR: 2.345, 95% CI: 1.309-4.203, P=0.004). Conclusion Serum Cystatin C ≥ 1.15 mg/L is an predictor of high risks of all-cause death, cardiovascular death, thromboembolic event and cardiovascular event in elderly non-vavular atrial fibrillation patients without renal insufficiency.关键词
心房颤动/血清胱抑素C/血栓事件/死亡率/老年人Key words
atrial fibrillation/cystatin C/thromboembolic event/mortality/aged分类
医药卫生引用本文复制引用
王海军,郭一洁,薛载耀,司全金,王玉堂..血清胱抑素C对不伴肾功能不全老年房颤患者心脑血管终点事件的影响[J].解放军医学院学报,2017,38(2):97-100,131,5.基金项目
解放军总医院科技创新苗圃基金(14KMM14) （14KMM14）
