解放军医学院学报2017，Vol.38Issue(3)：199-201,3.DOI:10.3969/j.issn.2095-5227.2017.03.003
促性腺激素释放激素激动剂预防腹腔镜子宫肌瘤剔除术后复发的疗效观察
Efficacy of GnRH-a in the prevention of recurrence of uterine myoma after laparoscopic myomectomy
摘要
Abstract
Objective To observe the clinical effecacy of GnRH-a in the prevention of recurrence of uterine myoma after laparoscopicmyomectomy. Methods Patients admitted to our hospital from June 2012 to June 2014 with uterine myoma were selected, ofwhich 82 cases were performed laparoscopic myomectomy. All the 82 patients were divided into the observation group (GnRH-atreatment group, 33 cases) and control group (simple operation group, 49 cases), respectively. The uterine volume changes andpostoperative recurrence of the two groups were compared. Results The difference of general data between the two groups was notsignificant. Uterine volumes in observation group were less than those in control group at 6 months (64.1±19.6 vs 80.3±27.2) cm3,12 months (59.0±23.7 vs 83.7±28.8) cm3, 18 months (62.9±24.3 vs 88.2±32.3) cm3 and 24 months (66.7±27.1 vs 95.6±34.9)cm3, with statistically significant differences (P < 0.001, respectively). Postoperative recurrence rate of observation group werelower than those of control group at 18 months (6.1% vs 22.4%, P=0.046) and 24 months (9.1% vs 30.6%, P=0.021) after operation,respectively. Conclusion GnRH-a can reduce uterine volume and recurrence in patients with uterine myoma after laparoscopicmyomectomy.关键词
子宫肌瘤/促性腺激素释放激素激动剂/腹腔镜子宫肌瘤剔除术Key words
uterine myoma/gonadotropin-releasing hormone-agonist/laparoscopic myomectomy分类
医药卫生引用本文复制引用
边立华,王楠,范文生,叶明侠,王敏,孟元光..促性腺激素释放激素激动剂预防腹腔镜子宫肌瘤剔除术后复发的疗效观察[J].解放军医学院学报,2017,38(3):199-201,3.基金项目
国家自然科学基金项目(81571411) Supported by the National Natural Science Foundation of China(81571411) （81571411）
