解放军医学院学报2017，Vol.38Issue(3)：232-235,4.DOI:10.3969/j.issn.2095-5227.2017.03.011
吡非尼酮不同给药方式对兔耳增生性瘢痕的影响
Therapeutic effects of oral or topical pirfenidone on pathological scar of rabbits ears
摘要
Abstract
Objective To explore the therapeutic effect of oral or topical administration of pirfenidone on hypertrophic scar of rabbits ears. Methods A total of 20 Japanese white rabbits(2.0 - 2.5 kg) were divided into 4 groups randomly. Animal model of hypertrophic scars was established in group A, group B and group C. Group A were fed with 0.5% pirfenidone powder mixed with food; Group B were treated with 8% pirfenidone ointment topically; Group C served as positive control while group D was the negative control. Two months after the surgery, hypertrophic scars were measured. Hematoxylin and eosin staining and Masson's trichrome staining were also performed. Results The hypertrophic scars of group A were thinner than those of group B and group C. HE and Masson's trichrome staining results also showed collagen reduced in group A. Conclusion Oral administration of pirfenidone had effect on inhibiting hypertrophic scar to some extent, while topical administration does not work significantly.关键词
瘢痕/吡非尼酮/兔Key words
cicatrix/pirfenidone/rabbit分类
医药卫生引用本文复制引用
李炳旻,周勇,杨怡,李恒进..吡非尼酮不同给药方式对兔耳增生性瘢痕的影响[J].解放军医学院学报,2017,38(3):232-235,4.基金项目
北京市自然科学基金项目 (7164299) Supported by the Beijing Natural Science Foundation Program (7164299) （7164299）
