检验医学与临床2017，Vol.14Issue(6)：754-755,758,3.DOI:10.3969/j.issn.1672-9455.2017.06.004
沈阳地区冠心病患者氯吡格雷药物代谢相关CYP2C19基因多态性分布分析
Analysis of polymorphism distribution of clopidogrel metabolism related gene CYP 2C19 in patients with coronary artery disease in Shenyang area
摘要
Abstract
Objective To analyze the genotype distribution of cytochrome P4502C19(CYP2C19) in the patients with coronary heart disease(CHD) in Shenyang area .Methods A total of 2601 patients with CHD receiving percutaneous coronary artery stent (PCI) in our hospital from April 2013 to December 2015 were selected as the research subjects .The PCR microarray gene chip was used to detect the clopidogrel metabolism enzymes related CYP2C19*1 ,*2*3 allele ,in which CYP2C19*1 encoded normal en-zyme activity .According to different CYP2C19 alleles ,the patients were divided into different types of clopidogrel metabolism ,in-cluding the extensive metabolizers (EM ,* 1/* 1) ,intermediate metabolizers (IM ,* 1/* 2 ,* 1/* 3) ,poor metabolizers (PM ,*2/*2 ,*3/*3 ,*2/*3) .Results The distribution of CYP2C19 genotype in CHD patients in Shenyang area from more to less was *1/*2 ,*1/*1 ,*2/*2 ,*1/*3 ,*2/*3 and *3/*3 respectively ,accounting for 40 .0% ,39 .1% ,9 .8% ,7 .4% ,3 .6%and 0 .1% of the total number of patients ;there was no statistically significant difference in gender (χ2 =5 .718 ,P=0 .335) .EM ,IM and PM clopidogrel metabolic type accounted for 39 .1% ,47 .4% and 13 .6% respectively ,there was no statistical difference in gen-der(χ2 =2 .310 ,P= 0 .315) .There was no statistical difference in clopidogrel metabolic type among different age groups (χ2 =11 .543 ,P=0 .317) .Conclusion About 60% of CHD patients undergoing PCI carry CYP2C19 *2 ,*3 afunctional gene ,but which has no relation to gender ,it is suggested that clopidogrel can be used in individualized treatment against platelet aggregation after PCI .关键词
冠心病/氯吡格雷/细胞色素P4502C19基因型/基因多态性Key words
coronary heart disease/clopidogrel/CYP2C19 gene polymorphisms/gene polymorphism引用本文复制引用
赵连爽,杨紫伟,代娣,郭晓临..沈阳地区冠心病患者氯吡格雷药物代谢相关CYP2C19基因多态性分布分析[J].检验医学与临床,2017,14(6):754-755,758,3.基金项目
国家卫生和计划生育委员会课题(201402018). （201402018）
