检验医学与临床2017，Vol.14Issue(6)：759-761,764,4.DOI:10.3969/j.issn.1672-9455.2017.06.006
非小细胞肺癌患者外周血CD4+T淋巴细胞亚群的变化及临床意义
Change of CD4+ T lymphocyte subsets in patients with non-small cell lung cancer and its clinical significance
摘要
Abstract
Objective To investigate the change of peripheral blood CD4+ T lymphocyte subsets in the patients with non-small cell lung cancer(NSCLC) and its clinical significance .Methods Sixty-eight cases of NSCLC in our hospital from April 2014 to Sep-tember 2015 were selected as the research subjects and contemporaneous 30 persons undergoing physical examination were taken as the control group .The levels of Th1 cells ,Th2 cells ,Th17 cells and Treg lymphocyte cells were examined between the two groups . Meanwhile the changes of peripheral blood T lymphocyte subsets in different clinical stages ,different pathological types ,whether having lymph node metastasis and different differentiation degrees were analyzed .Results (1)The proportions of peripheral blood Th2 cells and Treg cells in the NSCLC group were significantly higher than those in the control group (P<0 .05) ,while the Th1 cells proportion ,Th1/Th2 ,Th17 cells proportion and Th1/Treg were significantly lower than those in the control group (P<0 .05) .(2) The proportions of Th2 cells and Treg cells in the stage Ⅳ patients were significantly higher than those in the stage Ⅲpatients(P<0 .05) ,while the Th1 cells proportion ,Th1/Th2 ,Th17 cells proportion and Th17/Treg were significantly lower than those in the stage Ⅲ patients(P<0 .05) .(3)The Treg cells proportion in the patients with squamous cell carcinoma ,no lymph node metastasis or high-differentiation was significantly lower(P<0 .05) ,while the Th17 cells proportion and Th17/Treg were signifi-cantly higher(P< 0 .05);but the proportions of Th1 cells and Th2 ,and Th1/Th2 had no statistical difference (P> 0 .05) . Conclusion Peripheral blood Th1 cells ,Th2 cells ,Th17 cells and Treg cells are closely related with the development and progres-sion of NSCLC ,especially peripheral blood Th17 and Treg cells detection has an important clinical significance for judging the dis-ease condition and understanding the body immune function .关键词
非小细胞肺癌/T淋巴细胞亚群/CD4Key words
non-small cell lung cancer/T lymphocyte subsets/CD4引用本文复制引用
殷红梅,王磊,胡晓波,肖臻..非小细胞肺癌患者外周血CD4+T淋巴细胞亚群的变化及临床意义[J].检验医学与临床,2017,14(6):759-761,764,4.基金项目
上海市卫生局科研课题(20134266) （20134266）
上海市中医药事业发展三年行动计划(ZY3-CCCX-2-1002). （ZY3-CCCX-2-1002）
