检验医学与临床2017，Vol.14Issue(6)：765-767,3.DOI:10.3969/j.issn.1672-9455.2017.06.008
SF和Lp-PLA2水平与冠心病的相关性研究
Research on correlation between SF and Lp-PLA2 levels with coronary heart disease
摘要
Abstract
Objective To investigate the relationships between serum ferritin (SF) and plasma lipoprotein-associated phospho-lipase A2(Lp-PLA2) with coronary heart disease(CHD) .Methods One hundred and forty-two patients with CHD in the cardiolo-gy department of our hospital from February 2015 to March 2016 were selected and divided into the risk factors group and non-risk factors group according to whether containing risk factors .Other 58 people undergoing physical examination were chosen as the healthy control group .The SF level was detected by adopting the electrochemiluminescence immunoassay method and the plasma level of Lp-PLA2 was detected by adopting the double-antibody sandwich enzyme-linked immunosorbent assay .Results Compared with the healthy control group ,the SF and Lp-PLA2 levels increased significantly in both groups with and without risk factors ,the difference was statistically significant (P<0 .01) .The correlation analysis showed that SF and Lp-PLA2 levels in the groups with-out and with risk factors had no correlation (r=0 .055 ,0 .067 ,P>0 .05) .The Logistic regression analysis showed that SF and Lp-PLA2 were independently associated with CHD (OR=1 .898 ,1 .921 ,P<0 .05) .The positive rate of combined detection of SF and Lp-PLA2 levels in the two groups with and without risk factors was significantly higher than that in the single index detection ,the difference was statistically significant (χ2 =5 .469 ,P=0 .019;χ2 =4 .167 ,P=0 .041) .Conclusion SF and Lp-PLA2 can be used as the indicators of risk assessment in CHD and their combined detection has some predictive value for predicting CHD .关键词
血清铁蛋白/脂蛋白相关磷脂酶A2/冠状动脉粥样硬化性心脏病Key words
serum ferritin/plasma lipoprotein-associated phospholipase A2/coronary arterial atherosclerotic heart disease引用本文复制引用
李娟红,赵子贤,吴德彬,梁桂秀,陈世豪..SF和Lp-PLA2水平与冠心病的相关性研究[J].检验医学与临床,2017,14(6):765-767,3.基金项目
广东省江门市卫生计生系统科研项目(16A053). （16A053）
