检验医学与临床2017，Vol.14Issue(6)：800-802,3.DOI:10.3969/j.issn.1672-9455.2017.06.021
利拉鲁肽对2型糖尿病合并肥胖患者血清趋化素和胰岛素抵抗的影响
Influence of liraglutide on serum chemerin level and insulin resistance in patients with T 2DM complicating obesity
张星 1魏琦 1温维琴 1胡玉琴 1曹洁1
作者信息
- 1. 湖北省武汉市红十字会医院/湖北省武汉市第十一医院医务科 430015
- 折叠
摘要
Abstract
Objective To investigate the influence of liraglutide on serum chemerin level and insulin resistance in the patients with type 2 diabetes mellitus(T2DM ) complicating obesity .Methods Consecutive 80 T2DM patients with obesity were enrolled in this study and randomly divided into the liragluted group (n=40) and metformin group(n=40) .The serum chemerin level and IR related indexes were detected at the beginning of grouping and 3 months after treatment in the two groups ,including the homeosta-sis model assessment of insulin resistance(HOMA-IR) ,HOMA β cell function index(HOMA-β) ,area under the curve of insulin (INSAUC ) ,area under the curve of blood glucose(PGAUC ) and early insulin secretion index(ΔI30/ΔG30) .Results The levels of HO-MA-IR ,PGAUC and chemerin level after 3-months treatment in the liraglutide group were significantly decreased (P<0 .05) ,while HOMA-βand ΔI30/ΔG30 level were significantly increased(P<0 .05) .The comparison between the two groups showed that HO-MA-IR ,PGAUC and chemerin level in the liraglutide group were significantly lower than those in the metformin group (P<0 .05) , while the HOMA-βlevel was significantly higher than that in the metformin group(P<0 .05) .The liraglutide intervention was neg-atively correlated with ΔHOMA-IR and Δchemerin(r= -0 .665 ,-0 .699 ,P<0 .05) and positively correlated with ΔHOMA-β(r=0 .635 ,P<0 .05) .Conclusion The liraglutide intervention therapy may improve the IR degree in T 2DM patients with complicating obesity possibly by reducing serum chemerin levels .关键词
利拉鲁肽/2型糖尿病/肥胖/趋化素/胰岛素抵抗Key words
liraglutide/type 2 diabetes mellitus/obesity/chemerin/insulin resistance引用本文复制引用
张星,魏琦,温维琴,胡玉琴,曹洁..利拉鲁肽对2型糖尿病合并肥胖患者血清趋化素和胰岛素抵抗的影响[J].检验医学与临床,2017,14(6):800-802,3.
