昆明医科大学学报2016，Vol.37Issue(7)：19-21,3.
Let-7在正常乳腺组织和乳腺癌组织中的表达
Expressions of Let-7 in Normal Breast Tissue and Breast Cancer Tissue
摘要
Abstract
Objective To study the expression characteristics of Let-7 genes in breast cancer.Methods Twenty-eight patients with breast cancer were randomly selected,and their cancer tissue and adjacent normal tissue were collected.TRIzol was used to extract the total RNA and real-time quantitative PCR was used to detect the relative gene expression levels.Results The expression of precursor Let-7 in cancer tissue was (9.65 ± 2.31),which was lower than that in normal tissue (10.05 ± 2.81),P =0.048.Precursor Let-7 had dependence relationship with the long menstruation (b =0.816,P =0.029).The menarche age showed a positive correlation with precursor Let-7 in normal tissue (r =0.502,P =0.048) and a negative correlation in cancer tissue (r =-0.484,P =0.049) Conclusions The expression of precursor Let-7 in cancer tissue is lower than that in normal tissue.The period of menstruation is a protective factor to breast cancer.关键词
乳腺癌/Let-7/基因Key words
Breast cancer/Let-7/Gene分类
医药卫生引用本文复制引用
喻箴,肖明耀,崔明,刘敏,戴书颖,陈莹,何越峰..Let-7在正常乳腺组织和乳腺癌组织中的表达[J].昆明医科大学学报,2016,37(7):19-21,3.基金项目
云南省自然科学基金资助项目(2009CD081) （2009CD081）
云南省教育厅科研基金资助项目(2011Y176) （2011Y176）
