昆明医科大学学报2016，Vol.37Issue(11)：14-17,4.
云南省2009年至2014年B型流感毒株血凝素基因进化分析
Phylogenetic Analysis of Influenza B Hemagglutinin Gene in Yunnan from 2009 to 2014
摘要
Abstract
Objective To investigate the mutation of hemagglutinin gene and amino acid variation of influenza B.Methods Influenza B virus was isolated from throat swab samples in sentinel surveillance of Yunnan province from 2009 to 2014.HA1 gene sequence analysis was applied to determine 12 randomly-selected strains of influenza B virus.The results were analyzed,MEGA software was used to do homology comparison and HA gene phylogenetic tree was established.Results Differences on the serotype and genotype identification of influenza strains were found and it might be caused by inadequate gene mutation accumulation.Amino acid variations were found in 3 important regions of antigenic determinants in HA1 protein:ring 120,ring 150 and ring 160.The amino acid variation of position 131 in ring 120 was N131K,and in position 137 was N137H.Two strains had P187S mutation in position 187.Conclusion There are some important variations in the hemagglutinin gene of influenza B strains in Yunnan Province,with some variations being the same as vaccine strains and some being not.关键词
B型流感病毒/血凝素/HA1基因/氨基酸变异/进化分析Key words
Influenza B/Hemagglutinin/HA1gene/Amino acid variation/Phylogenetic analysis分类
医药卫生引用本文复制引用
曹亿会,李娟,赵晓南,宁德明,罗春蕊,徐闻..云南省2009年至2014年B型流感毒株血凝素基因进化分析[J].昆明医科大学学报,2016,37(11):14-17,4.基金项目
国家科技重大专项基金资助项目(2012ZX10004212) （2012ZX10004212）
