昆明医科大学学报2016，Vol.37Issue(11)：33-36,4.
多西紫杉醇联合伽马刀对肝癌细胞裸鼠皮下移植瘤凋亡作用的影响
The Apoptosis Effect of Docetaxel Combined with Gamma Knife on Hepatoma Cells Xenograft in Nude Mice
摘要
Abstract
Objective To explore the apoptosis effect of docetaxel combined gamma knife on hepatoma cell SMMC-7721 subcutaneous xenograft in nude mice.Methods Subcutaneous xenogyaft models were constructed and were divided into two groups:control group and experimental group.The experimental group was treated with docetaxel 60ug/0.3ml once every 3 days for 6 times and gamma irradiation once every other day for 6 times (with indoor temperature of 137Cs radiation source irradiating the tumor and of fractionated schedule 5Gy with the total dose of 10Gy every time).The control group was treated with physiological saline with the same dose of 60 ug/0.3 mL.Tumor growth was observed.Tumor samples were cut 30 days after the treatment and TUNEL was used to detect the apoptosis of tumor cells.Results Tumor growth rate in experimental group significantly slowed down.Apoptotic index in experimental groups was significantly higher than that in control group (P ＜ 0.05) Cornclusion Docetaxel combined gamma knife can inhibit the growth of hepatocellular carcinoma in nude mice.关键词
多西紫杉醇/伽马刀/裸鼠移植瘤/凋亡指数Key words
Docetaxel/Gamma knife/Xenograft in nude mice/Apoptotic index分类
医药卫生引用本文复制引用
李静娴,何迷,柳瑞,邢艺苑,简远熙,王家平,赵睿敏..多西紫杉醇联合伽马刀对肝癌细胞裸鼠皮下移植瘤凋亡作用的影响[J].昆明医科大学学报,2016,37(11):33-36,4.基金项目
云南省社会发展科技计划应用基础研究基金资助项目(2009ZC111M) （2009ZC111M）
