昆明医科大学学报2016，Vol.37Issue(12)：16-19,4.
迷迭香提取物对小鼠脑缺血的保护作用及急性毒性评价
Protective Effects of Rosemary's Extract on Cerebral Ischemia in Mice and Acute Toxicity Evaluation
摘要
Abstract
Objective To evaluate the protective effects of Rosemary's chloroform extract on cerebral ischemia in mice and acute toxicity.Methods The protective of rosemary's chloroform extract on cerebral ischemia was observed and compared by the mice models of cerebral anoxia and ischemia,thrombus formation in vivo,and chloroform induced arrhythmias.Rosemary's Chloroform Extract was given orally to mice to evaluate acute toxicity.Results Rosemary's chloroform extract had different degrees of inhibition of collagen-the adrenaline induced thrombus formation,and prolonged acute ischemic mice brains off mouth breathing time and increase the number of mouth breathing (P ＜0.05 or P ＜0.01);Chloroform extract significantly reduced the incidence of chloroform induced ventricular arrhythmias.Acute toxicity results suggested that a female rat died in the next day of chloroform extract group,no additional toxicity was observed.Conclusion Rosemary's chloroforrm extract has significant protective effect on cerebral ischemia and hypoxia in mice.关键词
迷迭香氯仿提取物/脑缺血/急性毒性Key words
Rosemary' s chloroform extract/Cerebral ischemia/Acute toxicity evaluation分类
医药卫生引用本文复制引用
张兰春,王尚文,胡炜彦,赵荣华,于浩飞,张荣平..迷迭香提取物对小鼠脑缺血的保护作用及急性毒性评价[J].昆明医科大学学报,2016,37(12):16-19,4.基金项目
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(2016FB014,2015FB006) （2016FB014,2015FB006）
云南省高校协同创新中心-南药研究协同中心基金资助项目(NY2014002) （NY2014002）
