林产化学与工业2017，Vol.37Issue(1)：81-86,6.DOI:10.3969/j.issn.0253-2417.2017.01.010
银杏叶聚戊烯醇纳米乳液联合抗生素抗菌活性研究
Antibacterial Activity of Ginkgo biloba Leaves PolyprenolsNanoemulsion in Combination with Antibiotics
摘要
Abstract
The synergistic antibacterial effects of Ginkgo biloba leaves polyprenols nanoemulsion (GBP) combined with five types of antibiotics,i.e., ampicillin (A), ciprofloxacin (C), gentamicin sulfate(G), erythromycin(E), and polymyxin B sulfate (P), were determined through analyzing the average diameter of the inhibition halos, minimal inhibitory concentration (MIC), fractional inhibitory concentration (FIC) index and the time-killing curves under sub-MIC conditions.The results showed that the antibacterial effect of polyprenols nanoemulsion combined with the antibiotics enhanced with the increase of the average diameter of polyprenols nanoemulsion.The antibacterial effect of polyprenols could be improved by nanoemulsion.The polyprenol combined with gentamicin sulfate had synergistic antibacterial effect against Staphylococcus aureus with the FIC index of 0.5, the diameter of the inhibition halos of (25.8±0.1)mm, and the MIC value of 33.0 mg/L.The time-killing curves showed that the antibacterial effect and the antibacterial time could be increased after polyprenols mixed with gentamicin sulfate.关键词
银杏/聚戊烯醇/纳米乳液/抗生素/抗菌作用Key words
Ginkgo biloba/polyprenol/nanoemulsion/antibiotic/antibacterial activity分类
化学化工引用本文复制引用
陶冉,王成章,叶建中,周昊,陈虹霞..银杏叶聚戊烯醇纳米乳液联合抗生素抗菌活性研究[J].林产化学与工业,2017,37(1):81-86,6.基金项目
中国林科院林业新技术所基本科研业务费专项资金(CAFINT2014C10) （CAFINT2014C10）
江苏省自然科学青年基金项目(BK20150070) （BK20150070）
江苏省林业三新工程项目(LYSX[2014]09) （LYSX[2014]09）
