临床口腔医学杂志2017，Vol.33Issue(3)：134-137,4.DOI:10.3969/j.issn.1003-1634.2017.03.003
60 Coγ射线对大鼠涎腺功能形态的影响
Effect of 60 Coγ rays on the function and morphology of salivary gland in rats
摘要
Abstract
Objective:To investigate the effect of 60 Coγ rays on the function and morphology of salivary gland in rats.Methods:Forty-eight adult male SD rats were randomly divided into 1,4,8 and 12 weeks for control and experimental groups,respectively.There were 8 groups that each group with 6 rats.After experimental groups were radiated with 60Coγrays on head and neck region in dose of 18 Gy,the rats were weighted every 6 days and taken the whole blood ,that the parotid gland tissue and saliva of them were tested .Results:After exposure to 60Coγrays,the weight,white blood cell count,red blood cell count and hemoglobin of rats decreased to the lowest after 6 days and then gradually increased .Even though there was an increasing trend on saliva flow and salivary amylase content , the experimental groups were lower than the control groups significantly ( P<0.05 ) .The acinar cells of experimental groups tended to become smaller , and the expression of AQP5 in the parotid gland was negatively correlated with the time in the experimental groups (P<0.05).Conclusion:60Coγrays have a little impact on the whole body ,but a great impact on salivary gland function and morphology .关键词
放射性损伤/SD大鼠/涎腺Key words
Radioactive damage/Rat/Salivary gland分类
医药卫生引用本文复制引用
孙喆,覃珊珊,张岩,王代友,吕秋丽,朱燕春..60 Coγ射线对大鼠涎腺功能形态的影响[J].临床口腔医学杂志,2017,33(3):134-137,4.基金项目
国家自然科学基金资助(81560187) （81560187）
