临床口腔医学杂志2017，Vol.33Issue(3)：156-159,4.DOI:10.3969/j.issn.1003-1634.2017.03.009
牙周炎对冠心病患者血管钙化影响的临床研究
Clinical research on the effect of periodontitis on the vascular calcification of coronary heart disease
摘要
Abstract
Objective:To explore the influence of periodontitis on vascular calcification related to coronary heart dis -eases .Methods:One hundred and fifty patients diagnosed with coronary heart disease or complicated by moderate and severe periodontitis were collected.They were divided into mild(group A),moderate(group B)or severe(group C)groups based on the luminal stenosis degree according to the coronary arteriography with 50 patients in each group ,and each group had 25 pa-tients(group A1,groupB1,group C1)with coronary heart disease and 25 patients(group A2,groupB2,group C2)with coronary heart disease complicated by moderate and severe periodontitis .The values of coronary artery calcium score ( CACS ) , blood lipid and C-reactive protein(CRP)level of all patients were calculated and analyzed ,and the clinical index in patients with periodontitis were compared .Results:Among three groups ,the coronary heart disease patients with moderate to severe peri-odontitis had a higher CACS than the patients with simple coronary heart disease (P<0.05).Blood fat and CRP level of ser-um in the patients with periodontitis (A2,B2,C2)were higher than those in patients without periodontitis (A1,B1,C1),and the difference had statistical significance (P<0.05).The periodontal clinical indices were different among group A 2,B2 and C2.At the same time,PD and CAL were significantly increased with the increase of coronary artery stenosis .Conclusion:Pe-riodontitis may contribute to the vascular calcification of the coronary heart disease patients .Meanwhile,coronary heart dis-ease can increase the destruction of periodontal tissue to some extent .关键词
冠心病/牙周炎/血管钙化/血脂/C-反应蛋白Key words
Coronary heart disease/Periodontitis/Vascular calcification/Blood fat/C-reactive protein分类
医药卫生引用本文复制引用
张艳慧,潘克清,时伯红..牙周炎对冠心病患者血管钙化影响的临床研究[J].临床口腔医学杂志,2017,33(3):156-159,4.基金项目
国家自然科学基金(81100755) （81100755）
