老年医学与保健2017，Vol.23Issue(1)：15-18,4.
老年高血压患者肝肾阴虚证的特征
Clinical Features of Elderly Hypertensive Patients with Deficiency Syndrome of Both Liver and Kidney Yin
摘要
Abstract
Objective To observe the clinical features and expression of marker genes in peripheral blood in elderly hypertensive patients with deficiency syndrome of both liver and kidney yin.Methods The correlation of hypertension grades and the course of the disease to deficiency syndrome of both liver and kidney yin was first studied;17 mRNA expressions with differentia were screened out from primary liver cancer patients with deficiency syndrome of both liver an kidney yin and from primary liver cancer patients with no deficiency syndrome of both liver and kidney yin by chromosomal microarray,and then the real-time fluorescence quantitative PCR technology was applied in observing if there existed the mRNA expressions same with the 17 in peripheral blood mononuclear cells of the elderly hypertensive patients with deficiency syndrome of both liver an kidney yin;the diagnostic model was set up based on the Receiver Operating Characteristic (ROC) curves.Results In total,the study enrolled 60 elderly hypertensive patients (＞ 65 years old),30 patients with deficiency syndrome of both liver and kidney yin while 30 patients with no;more elderly hypertensive patients got deficiency syndrome of both liver and kidney yin with the course of hypertension lasting;the MLH3 expression in peripheral blood mononuclear cells of the elderly hypertensive patients with deficiency syndrome of both liver an kidney yin decreased much more than that in patients with no deftciency syndrome of both liver an kidney yin while CD55 expression was enhanced,the difference was of statistical significance;ROC analysis showed that AUCMLH3=0.783 and AUCCD55 =0.737;the sensitivity of MLH3 and CD55 of the diagnostic model was 63.5 ％ and 57 ％ respectively.Conclusions MLH3 and CD55 may be the marker genes in elderly hypertensive patients with deficiency syndrome of both liver an kidney yin.关键词
老年/高血压/肝肾阴虚证/错配修复基因3/促衰变因子Key words
elderly/deficiency syndrome of both liver an kidney yin/MLH3/CD55引用本文复制引用
白玲玲,仲茂凤,杜娟,凌昌全..老年高血压患者肝肾阴虚证的特征[J].老年医学与保健,2017,23(1):15-18,4.基金项目
国家自然基金面上项目(81273881) （81273881）
