老年医学与保健2017，Vol.23Issue(1)：23-25,29,4.
Th17细胞及相关细胞因子在老年大肠癌患者中的作用
The Role of Th17 Cells and Related Cytokines in Elderly Patients with Colorectal Cancer
摘要
Abstract
Objective To investigate the role of Th17 cells and related cytokines in elderly patients with colorectal cancer.Methods 48 patients with colorectal cancer over 65 years old were enrolled in group A,32 patients with colorectal cancer under 65 years old in group B,48 norm over 65 years old in group C and 32 norm under 65 years old in group D;flow cytometry and Bio-Plex suspension chip technology were applied in detecting the proportion of Th17 cells and the levels of IL-17A、IL-17F、IL-21、IL-22 、IL-23 in peripheral blood of the patients and the norm while the immunofluorescence confocal microscope was applied in detecting the levels of IL-17 in cancer tissue and adjacent tissue.Results The percentage of Th17 cells in peripheral blood of the patients with colorectal cancer was higher than that of the norm (P＜0.05),and that in the elderly patients was higher than that in the young patients (P＜0.05);the levels of IL-17A,IL-21,IL-22 and IL-23 in peripheral blood of the patients with colorectal cancer were higher than those of the norm (P＜ 0.05);the levels of IL-17A,IL-23 in elderly patients were higher than those in young patients (P＜0.05);there existed no significant difference in the levels of IL-21,IL-22 between the elderly patients and the young patients (P＞0.05),and no obvious difference in the level of IL-17F among the 4 groups;the expression of IL-17 in cancer tissue was higher than that in adjacent tissues (P＜0.05),and that in the elderly patients was higher than that in young patients (P＜0.05).Conclusions Th17 cells are correlated to colorectal cancer and the age of patients,which may play a certain role in the occurrence and progress of colorectal cancer in elderly patients.关键词
Th17细胞/细胞因子/老年/大肠癌Key words
Th17 cells/cytokines/elderly/colorectal cancer引用本文复制引用
黄文海,俞建平,姚君良,李炳..Th17细胞及相关细胞因子在老年大肠癌患者中的作用[J].老年医学与保健,2017,23(1):23-25,29,4.基金项目
上海市金山区卫计委优秀青年人才培养项目(JWKJ-KTYQ-201205) （JWKJ-KTYQ-201205）
