国际眼科杂志2017，Vol.17Issue(3)：565-567,3.DOI:10.3980/j.issn.1672-5123.2017.3.48
8-羟基脱氧鸟苷在原发性翼状胬肉组织中的表达及意义
Expression and significance of 8-OHdG in primary pterygium
靳怀运 1王剑锋1
作者信息
- 1. 233000 中国安徽省蚌埠市，蚌埠医学院第一附属医院眼科
- 折叠
摘要
Abstract
· AIM: To detect oxidative DNA damage marker 8 -hydroxy- 2 - deoxyguanosine ( 8 - OHdG ) in primary pterygium and normal conjunctival tissues, explore the role of oxidative DNA damage in the pathogenesis of pterygium. <br> · METHODS: Totally 35 primary pterygium specimens were collected during surgery and 5 normal conjunctival specimens which above the normal temporal bulbar conjunctiva were collected. The expressions of 8-OHdG in pterygium tissues were detected by immunohistochemical method and compared with the normal conjunctival tissues. The difference of 8-OHdG expression between the two groups was compared. <br> · RESULTS: There were 24 ( 69%) pterygium specimens positive for 8-OHdG staining, limited to the nuclei of the epithelial layer. No substantial staining was visible in the subepithelial fibrovascular layers. All normal controls were negative for 8-OHdG staining. The difference of 8-OHdG expression between the two groups was statistically significant(P=0. 007). <br> ·CONCLUSION: The increased levels of 8-OHdG in the pterygium tissues indicate that oxidative DNA damage maybe play an important role in the pathogenesis of pterygium.关键词
翼状胬肉/8-羟基脱氧鸟苷/DNA氧化损伤Key words
pterygium/8-hydroxy-deoxyguanosine/oxidative DNA damage引用本文复制引用
靳怀运,王剑锋..8-羟基脱氧鸟苷在原发性翼状胬肉组织中的表达及意义[J].国际眼科杂志,2017,17(3):565-567,3.
