日用化学工业2017，Vol.47Issue(1)：52-56,5.DOI:10.13218/j.cnki.csdc.2017.01.011
高效液相色谱法测定化妆品中22种紫外吸收剂
Determination of 22 kinds of ultraviolet absorbent by high performance liquid chromatography in cosmetics
摘要
Abstract
An analytical method for simultaneous detection of 22 kinds of ultraviolet (UV ) absorbent in sunscreen cosmetics was established by using HPLC. After the cosmetic samples were extracted by tetrahydrofuran (THF)or mixed solvent with V (THF)∶ V (water)∶ V (methanol)=9∶6∶5,the extracted components were separated using Agilent C18 column with gradient elution by a mixed solvent composed of methanol-perchloric acid aqueous solution-THF-acetonitrile with flow rate of 1.0 mL/min,and detected by a diode array detector (DAD)at 311 nm. The results showed that 22 kinds of UV absorbent were separated and detected well. The linearity relationship is within 0.1 -500 mg/L. The correlation coefficient is greater than 0.999. The limit of quantification (LOQ)of all kinds of the UV absorbent is not higher than 4.6 mg/L. The spiked recovery rate is between 85.6% and 101.0%. In conclusion,the method was accurate and reliable with wide linear range,low LOQ and high sensitivity,which satisfies the requirement specified in China Safety and Technical Standards for Cosmetics (2015 edition).关键词
防晒化妆品/紫外吸收剂/高效液相色谱法/亚苄基樟脑磺酸/甲酚曲唑/甲酚曲唑三硅氧烷Key words
sunscreen cosmetics/ultraviolet absorbent/high performance liquid chromatography/benzylidene camphor sulfonic acid/cresol letrozole/drometrizole trisiloxane分类
化学工程引用本文复制引用
崔凤杰,谷婕,张坤,时文春,张慧敏..高效液相色谱法测定化妆品中22种紫外吸收剂[J].日用化学工业,2017,47(1):52-56,5.基金项目
国家质检总局科技计划资助项目 （）
