日用化学工业2017，Vol.47Issue(2)：87-89,103,4.DOI:10.13218/j.cnki.csdc.2017.02.006
当归净油抗衰老及抗炎祛痘功效的体外实验研究
In vitro test for examination of anti-senility and anti-inflammatory acne effects of absolute oil from Angelica sinensis (Oliv. )Diels
摘要
Abstract
Via a model of human dermal fibroblasts-adult (HDF-a),effects of Angelica sinensis absolute oil (ASO)on the secretion of collagen type Ⅰ (Col-Ⅰ)by the HDF-a cells were examined. Results showed that when the ASO is at its maximum safety mass concentration for the HDF-a cells 25 mg / L,the secretion of Col-Ⅰ in HDF-a cells can be effectively increased by 33. 5% . In addition,an inflammatory acne model was established by stimulating human acute mononuclear cells THP-1 cells with Propionibacterium acnes (P. acnes). Results showed that when ASO is at its maximum safety mass concentration for the THP-1 cells 12. 5 mg / L,the ASO can inhibit the release of inflammatory cytokines IL-1β from P. acnes treated THP-1 cells by 94. 51% . When the mass concentration is halved to 6. 25 mg / L,the ASO still can significantly inhibit IL-1β secretion by 64. 34% . Hence,ASO is a natural plant perfume raw material that displays anti-senility and anti-inflammatory acne effects in personal care activities and is expected to be further developed and applied in cosmetics.关键词
化妆品添加剂/当归/抗衰老/抗炎祛痘/植物天然香料Key words
cosmetic additive/Angelica sinensis/anti-senility/anti-inflammatory acne/perfume plants分类
化学化工引用本文复制引用
王玥,于海园,施雁勤,潘仙华,卢艳花,曹平..当归净油抗衰老及抗炎祛痘功效的体外实验研究[J].日用化学工业,2017,47(2):87-89,103,4.基金项目
教育和科研协同创新计划——上海市香料香精及化妆品协同创新中心资助项目(1021ZK162001) （1021ZK162001）
