肿瘤预防与治疗2017，Vol.30Issue(1)：57-61,5.DOI:10.3969/j.issn.1674-0904.2017.01.012
MicroRNA在缺氧诱导肿瘤生物学行为改变中的研究进展
Progress of Research on the microRNA in Hypoxia-induced Biological Behavior Changes of Tumors
摘要
Abstract
Hypoxiaisanimportantfeatureofthetumormicroenvironment.Hypoxiamicroenvironmentplaysanim-portant role in biological behavior changes of tumors,including tumor cell proliferation and apoptosis,angiogenesis,metab-olism,autophagy,invasion,and metastasis,etc.microRNA is an endogenous single-stranded non-coding RNA fragments with a length of 1 9 to 24 nt,binding to the target mRNA 3′-untranslated region (3′-UTR),to adjust the gene expression through the regulation of mRNA translation.It is an important regulatory factor in hypoxia-induced biological behavior chan-ges of tumors.This article provides a review of the regulation mechanism of microRNA in the biological behavior changes of tumors under hypoxia microenvironment.关键词
缺氧/肿瘤/microRNAKey words
Hypoxia/Neoplasm/microRNA分类
医药卫生引用本文复制引用
朱光辉,刘海军(综述),张学利(审校)..MicroRNA在缺氧诱导肿瘤生物学行为改变中的研究进展[J].肿瘤预防与治疗,2017,30(1):57-61,5.基金项目
国家自然科学基金资助项目 （）
