山东农业大学学报（自然科学版）2017，Vol.48Issue(1)：32-35,4.DOI:10.3969/j.issn.1000-2324.2017.01.007
泰山草乌生物碱对大鼠局灶性脑缺血的保护作用
Protection of Aconitum Alkaloids in Mount Tai against Focal Cerebral Ischemia in Rats
李红伟 1刘雪梅 1唐晓凤 1苏吉亮2
作者信息
- 1. 泰山护理职业学院, 山东 泰安 271000
- 2. 山东泰山疗养院, 山东 泰安 271000
- 折叠
摘要
Abstract
The aim of this research is to investigate the protection of aconitum alkaloids in Mount Tai on focal cerebral ischemic injury in rats. The permanent middle cerebral artery occlusion (pMCAO) in rats was adopted to establish cerebral ischemia model. The pMCAO postoperative rats were given aconitum alkaloids (20,50,100 mg?kg-1) by gavage. Evaluation index including cerebral infarction volume, water content and behavioral symptoms of brain were used to evaluate the protection of aconitum alkaloids in cerebral ischemia nerve. In rat focal cerebral ischemia body model, the high-dose group and middle-dose group of aconitum alkaloids could significantly reduce the cerebellum infarction volume, water content and improve brain behavior signs. The current finding provides the first evidence that aconitum alkaloids in Mount Tai have a direct neuroprotective activity in cerebral ischemic neuronal injury.关键词
草乌生物碱/脑缺血/pMCAOKey words
Aconitum alkaloids/cerebral ischemia/pMCAO分类
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李红伟,刘雪梅,唐晓凤,苏吉亮..泰山草乌生物碱对大鼠局灶性脑缺血的保护作用[J].山东农业大学学报（自然科学版）,2017,48(1):32-35,4.
