山东医药2016，Vol.56Issue(48)：24-27,4.DOI:10.3969/j.issn.1002-266X.2016.48.007
葡萄籽原花青素辅助治疗对中度OSAHS患者睡眠质量的影响及其机制
Effect of grape seed proanthocyanidin adjuvant therapy on sleep quality of OSAHS patients
摘要
Abstract
Objective To investigate the effect of grape seed proanthocyanidin extract (GSPE) adjuvant therapy on sleep quality of patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and its mechanism.Methods Totally 101 OSAHS patients were randomly divided into low-dose GSPE group (34 cases),high-dose GSPE group (33 cases) and control group (34 cases).The control group was treated with continuous positive airway pressure ventilation.Patients in the low-dose and high-dose groups were given orally GSPE 1 and 2 seeds/time,twice a day,and for 8 weeks.All subjects in the three groups received polysomnography before and after treatment.We recorded the longest time breathing low ventilation (MHT),hypopnea index (HI),the longest apnea time (LAT),apnea index (AⅠ),respiratory disturbance index (RDI),the lowest oxygen saturation (LSaO2),rapid eye movement (REM),and micro-awakening index (M-AI).The degree of subjective sleepiness was scored by Epworth Sleepiness Scale (ESS).The levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in serum were measured by enzyme-linked immunosorbent assay (ELISA) before and after treatment.Results The levels of MHT,HI,LAT,AI,RDI,M-AI,ESS and serum MDA were decreased in the three groups after treatment,the levels of LSaO2,REM and serum SOD were increased in the three groups after treatment as compared with those before treatment (all P ＜ 0.05).Compared with the control group,the levels of MHT,HI,RDI,MAI,ESS and serum MDA in low-dose GSPE group and high-dose GSPE group were decreased after treatment,the levels of LSaO2 and REM were increased after treatment,and the changes were more significant in the high-dose GSPE group (all P ＜ 0.05).There was no significant difference in LAT,AI and serum SOD between the three groups after treatment (all P ＞0.05).Conclusions GSPE adjuvant treatment can improve the sleep structure and sleep quality of OSAHS patients,and the mechanism may be the reduction of oxidative stress reaction.关键词
阻塞性睡眠呼吸暂停低通气综合征/葡萄籽原花青素/睡眠质量/氧化应激Key words
obstructive sleep apnea-hypopnea syndrome/grape seed proanthocyanidin extract/sleep quality/oxidative stress分类
医药卫生引用本文复制引用
李立群,樊蕴辉,王红阳,郭霞..葡萄籽原花青素辅助治疗对中度OSAHS患者睡眠质量的影响及其机制[J].山东医药,2016,56(48):24-27,4.基金项目
河北省医学科学研究重点课题(20150515). （20150515）
