实验动物与比较医学2017，Vol.37Issue(1)：76-82,7.DOI:10.3969/j.issn.1674-5817.2017.01.017
PI3K/Akt和AMPK信号通路在运动诱导的啮齿动物骨骼肌内GLUT4转位和表达中的作用
PI3K/Akt and AMPK Signaling Pathway and Effect of Exercise on Rodent Skeletal Muscle GLUT4 Translocation and Expression
摘要
Abstract
Skeletal muscles play an important role in glucose homeostasis.The translocation and expression changes of glucose transporter 4 (GLUT4) as one of the most important glucose transporter proteins in skeletal muscle are closely associated with insulin resistance.This paper reviewed the recent research progress on the exercise-induced translocation and expression of GLUT4 as well as the improvement of exercise-induced glucose uptake by phosphatidylinositol 3-kinases (PI3K) / protein kinase B (Akt) and AMP-activated protein kinase (AMPK) signaling pathways in rodent skeletal muscle.The purpose of this paper is to clearly understand the mechanism underlying GLUT4 translocation and expression in rodent skeletal muscles.关键词
骨骼肌/运动/胰岛素抵抗/葡萄糖转运体4(GLUT4)/磷脂酰肌醇-3-激酶(PI3K)/蛋白激酶B(Akt)/腺苷酸活化蛋白激酶(AMPK)Key words
Skeletal muscle/Exercise/Insulin resistance/Glucose transporter 4 (GLUT4)/Phosphatidylinositol 3-kinases (PI3K)/Protein kinase B (Akt)/AMP-activated protein kinase (AMPK)分类
生物科学引用本文复制引用
张云丽,王林,刘铁民..PI3K/Akt和AMPK信号通路在运动诱导的啮齿动物骨骼肌内GLUT4转位和表达中的作用[J].实验动物与比较医学,2017,37(1):76-82,7.基金项目
山东省自然科学基金资助项目(ZR2011CM040) （ZR2011CM040）
