同济大学学报（医学版）2017，Vol.38Issue(1)：40-43,4.DOI:10.16118/j.1008-0392.2017.01.008
IL-6促进胰岛细胞胰岛素分泌在PCOS发病机制中的作用
IL-6 induces insulin secretion in rat pancreatic islet cells in vitro
洪岭 1伍园园 1唐传玲 1陈淼鑫 1赵美 1滕晓明1
作者信息
- 1. 同济大学附属第一妇婴保健院生殖医学中心,上海201204
- 折叠
摘要
Abstract
Objective To investigate the effect of interlukin-6 (IL-6) on insulin secretion in rat pancreatic islet cells in vitro.Methods Primarily cultured pancreatic islet cells were treated with IL-6 at concentration of 10,100 and 1 000 pg/ml,respectively.The insulin contents in culture supernatant were detected by radioimmunoassay (RIA) at 24,48 and 72 h after culture.Results The insulin levels in culture supernatant with IL-6 1 000 pg/ml at 48 h after culture were significantly higher than those in controls (P ＜ 0.05).The insulin levels in supernatant with IL-6 100 pg/ml and 1 000 pg/ml were significantly higher than those controls at 72 h after treatment.Conclusion IL-6 can induce insulin secretion in pancreatic islet cells in vitro,which may be associated with hyperinsulinemia and insulin resistance involved in polycystic ovarian syndrome.关键词
白介素6/多囊卵巢综合征/胰岛素抵抗/胰岛Key words
intedukin-6/polycystic ovary syndrome/insulin resistance/pancreatic islet分类
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洪岭,伍园园,唐传玲,陈淼鑫,赵美,滕晓明..IL-6促进胰岛细胞胰岛素分泌在PCOS发病机制中的作用[J].同济大学学报（医学版）,2017,38(1):40-43,4.
