同济大学学报（医学版）2017，Vol.38Issue(1)：61-64,69,5.DOI:10.16118/j.1008-0392.2017.01.013
糖尿病患者结直肠癌代谢组学的研究
Tissue metabolomics in diabetic patients with colorectal cancer
摘要
Abstract
Objective To study on the changes of tissue metabolomics in diabetic patients with colorectal cancer.Methods The metabolomic profiles of the tumor tissue and adjacent normal tissue samples from 15 diabetic patients with colorectal cancer were studied by gas chromatography-mass spectrometry (GC-MS).Results Three hundred and thirty four biochemical molecules were detected.The metabolic status of the colorectal cancer tissue was significantly altered compared with that of adjacent normal tissue.Metabolomic profiling revealed that tumor tissue samples expressed lower levels of glucose,3-phosphoglycerate,and phosphoenolpyruvate (PEP) compared to adjacent normal tissue,with a corresponding increase in lactate production,showing an obvious Warberg effect in the glycometabolism.A strong upregulation of key intermediates in both purine and pyrimidine synthesis was observed and there was also a shift in glycerolipid metabolism with a noted decrease in glycerol and glycerol-3-phosphate.The levels of β-alanine,GPG (glycerophosphoglycerate) and pantothenate were increased in tumor tissue compared to control samples.Conclusion Metabolic derangements in the colorectal cancer tissue including alterations in many of metabolic pathways provide a constant supply to support metabolic demands for abnormal tumor growth and development.Such unique oncometabolites will help to evaluate in the early detection and treatment of colorectal cancer.关键词
结直肠肿瘤/糖尿病/代谢组学Key words
colorectal cancer/diabetes/metabolomics分类
医药卫生引用本文复制引用
徐佶,梁中林,崔龙,杨明..糖尿病患者结直肠癌代谢组学的研究[J].同济大学学报（医学版）,2017,38(1):61-64,69,5.基金项目
上海市教育委员会科研创新项目(13YZ023) （13YZ023）
