同济大学学报（医学版）2017，Vol.38Issue(1)：128-132,5.DOI:10.16118/j.1008-0392.2017.01.027
GnRH-A在不同卵巢功能患者超排中应用的研究进展
Application of gonadotropin-releasing hormone antagonist in controlled ovarian hyperstimulation for patients with different ovarian function
摘要
Abstract
Gonadotropin-releasing hormone agonists (GnRH-a)are widely used in controlled ovarian hyperstimulation (COH) at present in China.However,more and more studies show that long-term and large dose administration of GnRH-a would have an adverse effects on oocytes.Gonadotropin-releasing hormone antagonists (GnRH-A) have been used in human assisted reproduction technology (ART) since 1990s.As a competitive inhibitor of gonadotropin-releasing hormone (GnRH) receptors,GnRH-A can prevent the premature luteinizing hormone (LH) surge during COH,and GnRH-A has the advantages of fast action,short action duration and quick pituitary recovery.But it is controversial to use GnRH-A in patients with different ovarian responses.In this article,we will review the clinical application of GnRH-A in ART,focusing on its use in patients with different ovarian function.关键词
促性腺激素释放激素拮抗剂/人类辅助生殖技术/控制性超促排卵Key words
gonadotropin-releasing hormone antagonist/human assisted reproduction technology/controlled ovarian hyperstimulation分类
医药卫生引用本文复制引用
闫桂敏,王炎秋..GnRH-A在不同卵巢功能患者超排中应用的研究进展[J].同济大学学报（医学版）,2017,38(1):128-132,5.基金项目
国家自然科学基金重点项目(81430026) （81430026）
