生物骨科材料与临床研究2017，Vol.14Issue(1)：1-3,后插1-后插2,5.DOI:10.3969/j.issn.1672-5972.2017.01.001
几丁糖电纺膜完全修复硬膜后与正常硬膜对比研究
Comparative study of dura mater repaired by chitosan electrospun membrane complely and normal dura mater
郭兴锋 1朱冬梅 1陈建民 1侯春林 2窦源东2
作者信息
- 1. 南京中医药大学附属八一医院,江苏南京210002
- 2. 第二军医大学附属长征医院,上海200003
- 折叠
摘要
Abstract
Objective To study the difference of normal dura mater and newly grown dura mater after complete repair of dural defects with chitosan electrospun membrane.Methods Round bone windows (diameter=1.2cm) were operated on sixteen healthy adult New Zealand rabbits on bilateral sides symmetrically near the medial line.The dura mater was removed 0.8 mm by 0.8mm,where the chitosan membrane was placed in test group and the dura mater was not removed in control group.Eight weeks (when the dura mater was considered reconstructed) after surgery,observation and histology test were run to find the difference between the two groups.Results Postoperative observation showed no swelling,no bleeding,and no fester;and the chitosan membrane was tightly wrapped with no adhesion and leakage.HE staining showed the new grown fiber membrane was mature with no bFGF nor EGF expression.Conclusion Chitosan membrane is effective in repairing dura mater,and the new fiber membrane is histologically close normal meninges.关键词
几丁糖电纺膜/硬脑膜/对比研究Key words
Chitosan electrospun membrane/Dura mater/Comparative study分类
医药卫生引用本文复制引用
郭兴锋,朱冬梅,陈建民,侯春林,窦源东..几丁糖电纺膜完全修复硬膜后与正常硬膜对比研究[J].生物骨科材料与临床研究,2017,14(1):1-3,后插1-后插2,5.
