生物骨科材料与临床研究2017，Vol.14Issue(1)：4-9,6.DOI:10.3969/j.issn.1672-5972.2017.01.002
不同途径骨髓间充质干细胞移植后脊髓损伤大鼠运动功能比较的Meta分析
Comparison of motor function after intralesional, intravenous transplantation of Bone Marrow Stromal Cells in rats of spinal cord injury : a Meta analysis
摘要
Abstract
Objective To compare motor function after intralesional,intravenous transplantation of Bone Marrow Stromal Cells (BMSCs) in rats of spinal cord injury.Methods 6 studies were searched from Medline,EMbase,CNKI,The Cochrane Library,China Biology Medicinedisc and Wanfang data-base concerning intralesional,intravenous transplantation of BMSCs in treating spinal cord injury rats between 1990 and 2014 Oct,the data of the studies were collected and Meta-analyzed by RevMan 5.2.0 software,the studies were divided into 2 groups:within 3 days after spinal cord injury to transplant BMSCs (3 day group) and 7 days after spinal cord injury to transplant BMSCs (7 day group),and the BBB scale was meta-analyzed at 2weeks,4weeks,6weeks.Results 2 weeks after transplantation,no difference in BBB scale was found between intralesional and intravenous transplantation in 3 day group (WMD:-1.15 [-2.72,0.42],P=0.15),the BBB scale ofintralesional transplantation was higher than intravenous transplantation in 7 day group (WMD:-1.02 [-1.99,-0.05],P＜0.05);4 weeks after transplantation,no difference in BBB scale was found between intralesional and intravenous transplantation in 3 day group (WMD:-0.26 [-2.26,1.74],P=0.80),the BBB scale ofintralesional transplantation was higher than intravenous transplantation in 7 day group (WMD:-0.96 [-1.85,-0.07],P＜0.05);6 weeks after transplantation,no difference in BBB scale was found between intralesional and intravenous transplantation in 3 day group (WMD:2.56 [-4.39,9.51],P=0.47),the BBB scale ofintralesional transplantation was higher than intravenous transplantation in 7 day group (WMD:-1.72 [-2.71,-0.73],P＜0.05).Conclusion Within 3 days after spinal cord injury to transplant BMSCs no difference in motor fuction was found between intralesional and intravenous transplantation.7 days after spinal cord injury to transplant BMSCs,the motor function ofintralesional transplantation was better than intravenous transplantation.关键词
脊髓损伤/骨髓间充质干细胞/局部移植/静脉移植/BBB评分Key words
Spinal cord injury/Bone Marrow Stromal Cells/Intralesional transplantation/Intravenous transplantation/BBB scale分类
医药卫生引用本文复制引用
高中洋,李浩鹏,秦杰,宋辉,贺西京..不同途径骨髓间充质干细胞移植后脊髓损伤大鼠运动功能比较的Meta分析[J].生物骨科材料与临床研究,2017,14(1):4-9,6.基金项目
国家自然科学基金(批号:81571209) （批号:81571209）
