生殖医学杂志2017，Vol.26Issue(2)：99-105,7.DOI:10.3969/j.issn.1004-3845.2017.02.001
奇士肽神经内分泌网络与生殖功能调控
Kisspeptin neuroendocrine network and regulation of reproductive function
李江源1
作者信息
- 1. 解放军总医院内分泌科,北京 100853
- 折叠
摘要
Abstract
The discovery of kisspeptin became a new milestone in the regulation of human reproduction more than a decade ago,and it updated awareness of the neuroendocrine regulation of reproductive function.Kisspeptin neurons which synchronize with stimulatory signal from neurokinin B and inhibitory signal from dynorphin neurons to form the KNDy network have been identified to act upstream of GnRH neurons to control GnRH pulsatile secretion and the function of the hypothalamicpituitary-gonadal axis.KNDy neurons response to both negative and positive feedback signals of sex steroids and mediate the onset of puberty,which plays a pivotal role in connection between hypothalamic neuroendocrine network and energy metabolism of the body.关键词
奇士肽/神经内分泌网络/调控/生殖功能Key words
Kisspeptin/Nneuroendocrine network/Regulation/Reproductive function引用本文复制引用
李江源..奇士肽神经内分泌网络与生殖功能调控[J].生殖医学杂志,2017,26(2):99-105,7.
