生殖医学杂志2017，Vol.26Issue(2)：106-111,6.DOI:10.3969/j.issn.1004-3845.2017.02.002
绝经前乳腺癌术后辅助治疗对月经的影响
Impacts of adjuvant therapies on menstruation in patients with premenopausal breast cancer
关竞红 1马淼 2孙强 1陈蓉2
作者信息
- 1. 中国医学科学院北京协和医学院北京协和医院乳腺外科,北京 100730
- 2. 中国医学科学院北京协和医学院北京协和医院妇产科,北京 100730
- 折叠
摘要
Abstract
Objective:To investigate the impacts of adjuvant therapies on menstruation in the patients with premenopausal breast cancer.Methods:The data of 216 patients with premenopausal breast cancer inDepartment of Breast Surgery in Peking Union Medical College Hospital from September 2014 to February 2015 were retrospectively analyzed.The patients were divided into three groups according to the adjuvant therapies:chemotherapy only group,tamoxifen therapy only group,and chemotherapy combined with tamoxifen endocrine therapy group.The impacts of different adjuvant therapies on menstruation were investigated and the factors related with chemotherapy-induced amenorrhea were also explored.Results:Approximately more than half(58.3％) patients with chemotherapy developed amenorrhea.Only 3.6％ patients received tamoxifen treatment development amenorrhea nearly half(43.9％) of them developed irregular menstruation.Age,chemotherapy regimens and combined with tamoxifen treatment were associated with chemotherapy induced amenorrhea(CIA)(P＜0.05).In the patients Aged more than 40 years,anthracycline-based chemotherapy and combined with tamoxifen treatment were associated with increased probability of CIA(P＜0.05).Menstrual recovery was associated with age(P＜0.05).Age＞40 years old was associated with increased probability of permanent CIA (P ＜ 0.05),however,neither chemotherapy regimens nor tamoxifen usage were associated with it(P＞0.05).Menstrual recovery time of temporary amenorrhea was 8.0±2.5 months,and menstruation was almost no longer recovery if CIA time was more than 12.9 months.Conclusions:Chemotherapy for breast cancer can induce amenorrhea.The older age and anthracycline-based chemotherapy combined with tamoxifen treatment were more prone to amenorrhea.The patients received tamoxifen seldom develop amenorrhea.关键词
乳腺癌/辅助治疗/绝经前/月经状态Key words
Breast cancer/Adjuvant therapy/Premenopause/Menstrual states引用本文复制引用
关竞红,马淼,孙强,陈蓉..绝经前乳腺癌术后辅助治疗对月经的影响[J].生殖医学杂志,2017,26(2):106-111,6.
