摘要
Abstract
Objective:To investigate the predictive value of follicular output rate(FORT) and BMI on assisted reproduction outcome.Methods:The data of 4 865 patients undergone IVF-ET treatment in the First Affiliated Hospital of Zhengzhou University from January 2013 to December 2014 were retrospectively analyzed.The patients were divided into two groups according to pregnancy.The age,duration of infertility,BMI,basic FSH/LH ratio,FORT,number of antral follicles (AFC),days and dosage of gonadotropin (Gn) used,preovulatory follicle count(PFC),number of oocytes retrieved,2PN fertilization rate,high quality embryos rate,number of embryos transferred,number of embryos implantation,and total number of embryos were compared between the two groups.The patients were also divided to three groups according to FORT index(low/ medium/high) and the clinical and laboratory parameters were compared.The correlation between BMI and FORT was also tested.Results:The total dosage of Gn in pregnancy group was significantly lower than no-pregnancy group [(2 155.39 ± 890.62) IU vs.(2 400.22 ± 1 049.87) IU] (P＜0.05),but AFC,PFC,FORT,number of oocytes retrieved,total number of embryos,and the quality embryos rate were significantly higher than those in no-pregnancy group(P＜0.05).The total number of AFC and total dosage of Gn used were significantly decreased (P ＜ 0.05),but the numbers of PFC,oocytes retrieved and embryos significantly increased along with the increase of FORT among the low/medium/high FORT groups(P＜0.05).The high quality embryos rate in high FORT group was significantly less than that in the medium FORT or low group(70.81％ vs.67.20％,70.81％ vs.67.21％)(P＜0.05).Clinical pregnancy rate of low FORT group was less than the high or medium FORTgroup(49.22％ vs.54.25 ％,49.22 ％ vs.55.20％)(P＜0.05).The days and total dosage of Gn used in normal BMI group were significant lower than those in over BMI group(P＜0.05).The number of oocytes retrieved,total embryos,and clinical pregnancy rate in normal BMI group were significantly higher than over BMI group (P＜0.05).There was no linear correction between the FORT and the BMI.Conclusions:FORT index can predict ovarian response,embryonic development potential in assisted reproductive patients.Controlled BMI to normal level can improve the IVF/ICSI pregnancy outcome in overweight patients.关键词
卵泡输出率/体重指数/辅助生殖Key words
Follicular output rate/BMI/ART
