生殖医学杂志2017，Vol.26Issue(2)：127-132,6.DOI:10.3969/j.issn.1004-3845.2017.02.005
高孕激素状态下促排卵方案用于卵巢正常反应患者IVF-ET的自身对照研究
Progestin primed ovarian stimulation protocol in normal ovarian responders in IVF/ICSI: a self-controlled study
郭丽娜 1贾新转 1吕翠婷 1王楠 1董翠1
作者信息
- 1. 河北医科大学第四医院生殖医学科,石家庄050011
- 折叠
摘要
Abstract
Objective:To explore the clinical effect of progestin primed ovarian stimulation(PPOS) protocol in normal ovarian responders who failed to get pregnancy in the first cycle IVF/ICSI with conventional long protocol.Methods:The data of 42 normal ovarian responders who failed to get pregnancy with long protocol at the first cycle,and then were administrated with PPOS protocol in the next cycle in our center from Jan.2014 to Nov.2015 were analyzed retrospectively.The levels of LH,E2,progesterone on the trigger day,duration and total dosage of gonadotropin(Gn) used,number of oocytes retrieved,MII oocytes,fertilization rate,high quality embryos rate,and implantation rate and clinical pregnancy rate were compared between the two groups.Results:The duration [(10.33 ± 2.00) vs.(13.00 ± 2.27) days] and total dosage of Gn used [(2 325.00±449.08)U vs.(3 182.98±904.91)U] with PPOS protocol were significantly less than those with long protocol(P＜0.05).The LH levels [(1.64± 1.31)U/L vs.(0.91± 1.01) U/L] were significantly higher,and progesterone levels [(2.25 ± 0.86) nmol/L vs.(3.87 ± 1.68) nmol/L)] were significantly lower in PPOS protocol cycles compared with long protocol cycles(P＜0.05).Although the number of oocytes retrieved,MII oocytes,2PN embryos,available embryo were not significantly different (P＞0.05),the fertilization rate [(71.82± 17.64)％ vs.(63.75 ±15.77) ％] and high quality embryos number [(3.62± 1.97) vs.(2.79 ± 1.65)] and rate [(62.21 ± 24.04) ％ vs.(48.48 ± 22.53) ％] were significantly increased in PPOS protocol cycles (P ＜ 0.05).The clinical pregnancy rate (47.83％ vs.7.02％) and implantation rate(24.74％ vs.3.64％) were significantly improved in the FET cycles with PPOS protocol(P＜0.05).Conclusions:PPOS protocol can provide better clinical outcome for the patients with ovarian normal response but failed to get pregnancy with long protocol in IVF/ICSI.It provides a new option for ovulation induction.关键词
卵巢正常反应/长方案/孕激素/卵巢刺激/体外受精-胚胎移植Key words
Normal ovarian responder/Long protocol/Progestin/Ovarian stimulation/IVF-ET引用本文复制引用
郭丽娜,贾新转,吕翠婷,王楠,董翠..高孕激素状态下促排卵方案用于卵巢正常反应患者IVF-ET的自身对照研究[J].生殖医学杂志,2017,26(2):127-132,6.
